GAST and gastric ulcer: First, gastric mucosa is stimulated by ethanol resulting in numerous blood spots and erosion, and persistent injury leads to disorders associated with the secretion of gastrointestinal hormones (including GAS and MTL) in gastric tissues and damage of microvessel endothelial cells, which in turn, affects blood flow and oxygen supply in gastric mucosal tissues, oxidative stress, mucosal injury and necrosis, and further aggravation of gastric ulcers (24-27).