Likewise, Huang et al., stated that qufengtongluo (QFTL), in addition to repressing renal levels of PI3K and p-AKT, down-regulates transforming growth factor-beta (TGF-β) expressions in the kidneys and ameliorates albuminuria in type 2 diabetic rats (22). The gene discussed is TGFB1; the disease is type 2 diabetes mellitus.