Since cell apoptosis plays an important role in the pathology of T2DM, we determined the changes of classical apoptosis indexes in pancreases by Western blotting: the apoptosis-promoting protein - Bax, the apoptosis suppression protein - Bcl-2, and the effector caspase protein - Caspase3 (Figure 2A). Here, BCL2 is linked to type 2 diabetes mellitus.