According to densitometric analysis in Figures 2B and 2C, the ratio of Bax to Bcl-2 protein (Bax/BCL-2) and the cleaved-Caspase3 (c-Caspase3, the activated Caspase3) in the db/db group were all elevated when compared with those in the db/m group (P<0.01), suggesting that cell apoptosis in diabetic pancreases were increased. This evidence concerns the gene BCL2 and diabetes mellitus.