Harnessing of MSCs in gene therapy of pancreatic cancer has been investigated by inserting several genes such as IL15, IFN- β, miRNAs (miR-126 and miR-1231), TRAIL, HSV-TK, and NK4 into MSCs to release encoded products directly or indirectly with exosomes. Here, TNFSF10 is linked to familial pancreatic carcinoma.