COL18A1 and neoplasm: Accumulating evidence emphasizes the antiangiogenic capability of endostatin via suppression of Wnt signaling pathways in different cancer types (97, 98). The expression of endostatin in PMSCs, which was transduced using adenovirus, resulted in the reduction of angiogenic ability in CRC cell lines, decreased the number of tumor nodules, and increased tumor cell apoptosis and survival time in the mice model (99).