On the one hand, they reported increased apoptosis and benign trans-differentiation compared with reprogramming to cancer stem cells; whilst on the other hand, they showed that augmented expression of DUSP6/MKP3 in the MAPK pathway was responsible for induction of apoptosis and suppression of growth suppression, both in vitro and in vivo (58). The gene discussed is DUSP6; the disease is cancer.