They elucidated that the combination of this engendered MSCs with low-dose doxorubicin deterred HepG2 cell proliferation and tumor growth in the HepG2 xenograft mouse model (116). Other research groups delineated that intravenous injection of BMSC-PEDF in the HCC orthotopic nude mouse model decreases tumor volume, angiogenesis, and lung metastasis (117). This evidence concerns the gene SERPINF1 and neoplasm.