Naïve MSCs with their secreted molecules lead to deregulation of several proteins and different signaling pathways such as down-regulation of FAK, X-linked inhibitor of apoptosis protein (XIAP), Akt, PI3K, NFkB, and Wnt pathway, or up-regulation of PTEN and TRAIL which ultimately results in tumor eradication (34, 35). The gene discussed is TNFSF10; the disease is neoplasm.