Stable expression of IFN-α2b in the IFN-α2b gene-modified BMSCs resulted in inhibition of HCC cell proliferation and increased cell cycle arrest in HCC cell lines (HepG2 and Huh7) and also suppression of tumor growth in vivo via repression of the Notch signaling pathway (107). Here, IFNA2 is linked to hepatocellular carcinoma.