NPM1 and neoplasm: Among the identified genes negatively regulating cell proliferation, including Npm1, Eif3e, Cbx3, Psmc6, Fgf7, Fxr1, Ddx3x, Mbnl1, and Cdc27, Npm1, a gene of nuclear phosphoprotein, is involved in the regulation of cell death by mutation, deregulation, or chromosomal translocation in many tumor types, and its reduced expression can promote the proliferation of osteoblasts and the ablation of osteoclasts [33].