APP and Senile plaques: Intrinsic andextrinsic perturbations such as genetic mutations, cellular stress,modifications, inflammation, and other signaling anomalies in neurons contributeto alterations in biosynthesis and activity of BACE, which includes aresidue-specific cleavage of APP that leads to the formation of insolubleamyloid-beta (Aβ) or insoluble senile plaques [17,89].