However, since the etiology of neurodegenerative diseases aremultifactorial that mainly involves signaling through membrane proteins and thepharmacological activities of the spider venom compounds that target membraneproteins, this shows that they can also be studied to modulate other membraneproteins, aside from AChE, with the focus on discovery and development ofcholinergic-related compounds. This evidence concerns the gene ACHE and neurodegenerative disease.