Regulation of ACh is conducted by apost-synaptic acetylcholinesterase (AChE) to modulate synaptic transmission [15,16].However, in neurodegenerative diseases, an increase in activities of AChEimmediately decreases ACh transmission, which results in a lack of downstreamsignaling in post-synaptic neurons that promotes aberrant activities ofbeta-secretase (BACE) [17]. This evidence concerns the gene ACHE and neurodegenerative disease.