PMN then transmigrate through the endothelial cell junctions and moveinto the tissues towards the infection site, attracted by severalchemoattractants such as PAF, LTB4, IL-8, the C5a fraction of the complement andthe bacterial peptide fMLP (N-formyl-methionyl-leucyl-phenylalanine) (Figure 1). The gene discussed is CXCL8; the disease is infection.