The available data demonstrate that (i) The FBXL7 expression is decreased in PCa tissues compared to adjacent controls, (ii) FBXL7 inhibition enhanced migration and invasion of PCa cells, (iii) FBXL7 represses the EMT process of PCa, (iv) FBXL7 induces Snail 1 ubiquitination and proteasomal degradation, and (v) FBXL7 inhibition facilitated tumor metastasis in vivo. Here, FBXL7 is linked to neoplasm.