Mounting evidences have revealed the role of F-box proteins in regulating EMT in multiple types of tumors, including FBXW7 in lung cancer and gastric cancer (Li et al., 2016; Zhang et al., 2018), FBXO11 in breast cancer and gastric cancer (Zheng et al., 2014; Jin et al., 2015), and FBXO45 in prostate cancer and PCa (Abshire et al., 2016; Wang et al., 2018). The gene discussed is FBXO45; the disease is breast cancer.