To further expound the mechanism that FBXL7 regulates the EMT of PCa cells, we explored 4 upstream transcription factors, Snail 1, Snail 2 (Wawruszak et al., 2019), ZEB1 (Goossens et al., 2017; Cho et al., 2019), and Twist (Rout-Pitt et al., 2018), which have an essential role in regulating EMT. Here, ZEB1 is linked to posterior cortical atrophy.