FBXL7 knockdown inhibits E-cadherin expression, and increases Vimentin and N-cadherin expression, whereas FBXL7 overexpression increases E-cadherin expression and decreases Vimentin and N-cadherin expression, indicating that FBXL7 represses the EMT of PCa cells. The gene discussed is CDH1; the disease is posterior cortical atrophy.