The frequency of haplotype PLCG1 (rs753381-rs2228246, C-G) was lower in NIUA patients (mainly presenting angioedema), while that of TNFRS11A rs1805034-rs35211496 (C-T) was higher among patients with NIUA mainly presenting urticaria or those presenting both urticaria and angioedema, compared to control groups (Ayuso et al., 2015a). The gene discussed is PLCG1; the disease is urticaria.