AKT1 and cancer: Reprogramming of metabolism in cancer cells is regulated by multiple factors and signaling pathways, such as hypoxia inducible factor (HIF-1), Myc, p53, and the PI3K/Akt/mTOR pathway (Pelicano et al., 2006; Dang et al., 2009; Liao et al., 2009; Masui et al., 2013).