Overexpression of Hyp-1 in both tobacco (N. tabacum) and lettuce (Lactuca sativa) found that Hyp-1 localized to the nucleus, plasma membrane and cytoplasm of epidermal cells and was found to confer resistance to bacterial infection with Agrobacterium tumefaciens (Hou et al., 2019). Here, PHEX is linked to bacterial infectious disease.