Our study found that: 1) JSS patients differed from non-JSS with respect to hypergammaglobulinemia, cytopenias, USFR, MSG lip biopsy, SGUS, history of parotitis/glandular swelling, sicca symptoms (both dry eyes and dry mouth), and dental caries, 2) Potentially applicable levels of sensitivity and specificity of autoantibodies to distinguish JSS from non-JSS were found only in cSjA, 3) Anti-CA6 IgG was the most prevalent eSjA in both groups, but was not specific for JSS. This evidence concerns the gene CA6 and medical procedure.