NFKB1 and asthma: On the other hand, IL-37 not only targets TSLP through NF-κB and ERK1/2 signaling pathways (105), but also may act on tracheobronchial epithelial cells to inhibit fibroblasts and AMSC from producing CCL11, thereby alleviating house dust mite(HDM)-induced asthma (106).