Certain polymorphisms in non- hypercholesterolemia individuals are related to the risk of having high LDL-C and glucose levels, high risk of T2DM, and low risk of having abundant visceral abdominal fat, revealing that some IL-37 polymorphisms are associated to cardiometabolic factors in both individuals with and without hypercholesterolemia (51). The gene discussed is IL37; the disease is familial hypercholesterolemia.