In humanized NOD/SCID mice with HDM-induced asthma, the intravenous injection of IL-37b restores normal levels of the eosinophil activators CCL11 and IL-5 in the plasma, and inhibits the increase of Th2, cytokines related to asthma such as IL-4, IL-6, and IL-13, and the level of inflammatory IL-17, CCL5, and CCL11 in lung homogenate (107). This evidence concerns the gene IL4 and asthma.