MSCs overexpressing IL-37 injected into the tail vein of MRL/lpr mice resulted in a better mice survival rate, less SLE signs, significantly decreased pro-inflammatory factors, less total antibody and autoantibody levels, as well as T cell number in serum and kidneys compared with mice that received only control MSCs or IL-37 treatment (72). Here, IL37 is linked to systemic lupus erythematosus.