TP53 controls the expression of multiple immunosuppression-associated proteins such as PD-L1 (also known as CD274), VISTA (also known as VSIR), NKG2D (also known as KLRK1), and FOXP3; loss or mutation of TP53 in cancers changes cytokine secretion, resulted in reshaping the immune microenvironment to promote immune escape of cancer (36, 37). This evidence concerns the gene CD274 and cancer.