CD4 and neoplasm: Significantly, IL12 secreted by genetically modified chimeric antigen receptor (CAR) T cells have also been shown to modulate the OvCa TME through multiple mechanisms, including reactivation of anergic tumor-infiltrating lymphocytes, inhibition of Treg-mediated suppression of effector T cells, and induction of Th1 CD4+ T cells to the tumor site (80).