found that lentiviral transduction of tumor ascites lymphocytes (TALs) with chemokine receptor CXCR2 significantly increased migration of TALs towards rhIL8 and autologous ascites, which provides the proof of concept that engineering TALs with a chemokine receptor is feasible and can improve homing of transduced TALs towards the OvCa microenvironment (89). This evidence concerns the gene CXCR2 and neoplasm.