High levels of miR-424(322) in tumors are correlated with improved progression-free survival and, in a syngeneic OvCa mouse model, overexpression of miR-424(322) in the OvCa cells increased the number of cytotoxic CD8+ T cells and decreased the number of MDSCs and Tregs in the TME, reduced tumor growth, and enhanced the efficacy of chemotherapy (59). The gene discussed is CD8A; the disease is neoplasm.