TNF and ovarian carcinoma: evaluated the immune response patterns through analysis of type 1 (Th1), type 1(Th2), and type 17(Th17) cytokines in patients with epithelial ovarian cancer (EOC), and found higher levels of TNF-α/IL-4/IL-6/IL-10 in EOC patients compared to the control, IL-10 and TNF-α concentrations were higher in stage III/IV and associated with higher CA125, higher Th1 immune response was observed when the cytoreduction was considered optimal, while higher concentrations of Th2 cytokines were associated with unsatisfactory cytoreductive surgery and undifferentiated tumors (17).