Regarding myeloid cell phenotype role in viral infection prognosis, a M1-like shift, correlated with secretion of cytokines like IFN-γ, TNF-α, IL-6, and IL-12, both in mucosal associated and in systemic myeloid cells, was considered determinant for worse outcomes in life-threatening viral infection (21, 22). Here, IFNG is linked to viral infectious disease.