However, in most cancers, including non-small-cell lung carcinoma, gastroesophageal cancer, urinary neoplasm, and hepatocellular carcinoma, PD-L1/PD-1 blockade alone is only effective in a small proportion of patients (with objective response rates ranging from 15% to 25%) (57). The gene discussed is PDCD1; the disease is hepatocellular carcinoma.