In another study, in a murine arthritis model, quercetin treatment reduced IL-1β and TNF-α release, and inhibited levels of pre-pro-endothelin 1 and cyclooxygenase 2 mRNA by inhibiting the activation of NF-κB and heme oxygenase 1/Nrf2 signaling (43). The gene discussed is HMOX1; the disease is Arthritis.