(47) reported that quercetin reduced this osteoclast differentiation when CD14+ monocytes were cultured with IL-17-prestimulated RA-FLSs or Th17 cells, and it reduced IL-17-induced receptor activator of nuclear factor kappa-Β ligand (RANKL) levels in RA-FLSs, and inhibited the activation of the mammalian target of rapamycin. The gene discussed is IL17A; the disease is rheumatoid arthritis.