The cytosolic sensors cyclic GMP-AMP synthase (cGAS), interferon-activable protein 204 (IFI204), and absent in melanoma 2 (AIM2) recognize M. tuberculosis DNA, while retinoic acid-inducible gene-I (RIG-I), melanoma differentiation‐associated protein 5 (MDA5), and protein kinase R (PKR) detect RNA (22). The gene discussed is EIF2AK2; the disease is melanoma.