These results are in line with previously published evidence demonstrating that PTX3 serum levels are not significantly affected by various treatments for inflammatory arthritis, either cs-DMARDs (methotrexate) or anti-TNF or a combination of both, at different timepoints (6 weeks or 6 months) in a cohort including patients with RA, psoriatic arthritis and spondylarthritis (31). This evidence concerns the gene PTX3 and rheumatoid arthritis.