CD30 (TNFRSF8), a cell membrane protein and tumor marker belonging to the TNF receptor family, is found on the surface of NHL cells including DLBCL, anaplastic large cell lymphoma (ALCL), PMBCL (212), adult T-cell leukemia/lymphoma (213), and peripheral T cell lymphoma (PTCL) (214), as well as in HL, and rare solid tumors (215). Here, TNFRSF8 is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.