Our results showed that mice fed HFD exhibit increased expression of CXCR3 expressing CD8+ T cells and IFN-γ expressing CD4+ T cells which recruit and induce the number of macrophages their polarization towards M1, Th1 response, resulting in sustained low-grade chronic inflammation during obesity in mice. Here, CXCR3 is linked to obesity due to melanocortin 4 receptor deficiency.