However, the density of extratumoral secondary follicular TLS and extratumoral BCL6- germinal centers in early locoregional lymph node samples was lower than in distant late lymph node metastases (FDR = 0.002 and 0.003, respectively, Wilcoxon’s rank sum test) and was not different to distant late skin metastases (FDR = 0.29 both, Wilcoxon’s rank sum test). The gene discussed is BCL6; the disease is metastatic malignant neoplasm in the lymph nodes.