BCL6 and metastatic neoplasm: When we further compared early locoregional and late distant metastatic tumors, we observed an increase in the density of particularly extratumoral secondary follicular TLS and BCL6- germinal centers in late distant metastatic tumors (P = 0.05 and 0.03, FDR = 1.0 and 0.875, respectively, Wilcoxon’s rank sum test).