Additionally, Fcgr2b-/- mice develop age-dependent lupus characteristics, including asymptomatic lupus prone (less than 16 weeks old), asymptomatic lupus with anti-dsDNA (16-24 weeks old) and full-blown lupus (40 weeks old), which have been used as a representative model of lupus (8). Here, FCGR2B is linked to systemic lupus erythematosus.