Extracellular DNA networks from NETosis, both of NADPH oxidase 2 (NOX2)-dependent and NOX2-independent pathways, enhance exposure of nuclear contents (16), including dsDNA that is normally contained in nuclei (17), and increased anti-dsDNA which is a specific auto-antibody in lupus (18, 19). The gene discussed is CYBB; the disease is systemic lupus erythematosus.