Indeed, PAD4 inhibitor decreased NETs (serum dsDNA, serum MPO, and glomerular NETs) at 24 h post-renal I/R and attenuated lupus characteristics (anti-dsDNA, proteinuria and Scr) at 120 h post-renal I/R (Figures 11A–G) supporting an impact of NETs formation on anti-dsDNA production and lupus exacerbation. Here, MPO is linked to systemic lupus erythematosus.