The lowest values of PAPP-A were found in PE woman reaching 86.57 pg/ml median (min = 75.26; max = 99.28) while for gestational hypertension women (GH), the median was 90.39 pg/ml (min = 74.24; max = 103.0) and for the control group 97.66 pg/ml (min = 66.61; max = 108.2). This evidence concerns the gene PAPPA and preeclampsia.