To examine B cell phenotypes in D-LC caused by HBV, we performed flow cytometry using a panel of 11 markers (18) (CD19, CD10, CD38, IgD, CD21, CD27, CCR7, CXCR3, CXCR4, CXCR5, and IL-21R) and demonstrated the changes of B cell subsets for the first time in HBV-associated advanced cirrhosis. The gene discussed is CXCR5; the disease is Cirrhosis.