Taken together, our results have demonstrated that, first, human heart EC and mouse aortic EC express all four types of coronavirus receptors such as ANPEP, CEACAM1, ACE2, DPP4 and virus entry facilitator TMPRSS2 (human heart endothelial cells); second, most of coronavirus RTC are expressed in human microvascular EC, which may contribute to coronavirus viremia, thromboembolism, and CVDs (Figure 3K); and third, use of RTC for coronavirus replication and transcription may have cell-type specificity. This evidence concerns the gene ACE2 and Thromboembolism.