Similarly, EC execute innate antiviral machinery by inducing expression of several immunomodulatory genes in response to IFNs and to double-stranded RNA (dsRNA) (39); and the early intervention of EC to produce dsRNA protein kinase and activate intrinsic and extrinsic apoptotic pathways is of vital importance in restricting viral dissemination and eliminating viral infection (40). This evidence concerns the gene WEE1 and viral infectious disease.