Human heart EC and mouse aortic EC express all four types of coronavirus receptors such as ANPEP, CEACAM1, ACE2, DPP4 and virus entry facilitator TMPRSS2 (human heart); most of coronavirus replication-transcription protein complexes are expressed in human microvascular EC, which contribute to viremia, thromboembolism, and CVDs. The gene discussed is ACE2; the disease is Thromboembolism.