CD8A and neoplasm: In the future, we need comprehensively study the multi-omic features including genomic, transcriptomic, proteomic, metabolic and epigenomic features, especially single-cell transcriptome analysis and TCR sequencing of both primary lesions and LM to unravel the impact of specific immune clusters (e.g. macrophages, CD8+ T cells, Tregs, etc.)on tumor progression in the liver and ICI response, and then establish the true predictive or prognostic significance of LM in patients received ICIs therapy.