CD8+ T cells from adults with DS are reduced in naïve subsets and enriched in differentiated subsets that express higher levels of activation and senescence markers (e.g., IFN-γ, Granzyme B, PD-1, KLRG1), and over-produce cytokines associated with autoimmunity (e.g., TNF-α) (69). The gene discussed is TNF; the disease is Dravet syndrome.