This has been recently demonstrated in a comprehensive study characterizing the peripheral T cell compartment in adults with DS, where it was shown that CD8+ T cells from participants with DS stimulated in vitro responded more potently than their euploid counterparts, overproducing TNF-α, IFN-γ, IL-2, and MIP-1α, MIP-1β, Eotaxin, GM-CSF, IL-8, IL1-RA, and IL-10 (69). The gene discussed is TNF; the disease is Dravet syndrome.