TNF and COVID-19: A hallmark of disease severity in COVID-19 is the uncontrolled inflammatory response, with the detection of IL-6, IL-17, TNFα, and GM-CSF at the serum/blood level (Chen G. et al., 2020; Mehta et al., 2020; Parra-Medina et al., 2020), the so-called “cytokine storm.” Here we showed a significant increase of those cytokines in the oral cavity of COVID-19 patients, indicating the development of inflammation right at the entry site of the virus.