ACBD3 and infection: Using infection models of Enteroviruses A71 (EV-A71), D68 (EV-D68), Rhinovirus, and Poliovirus various groups have demonstrated that 3A protein binds with GOLD domain of ACBD3 and knockdown of either ACBD3 or PI4KIIIβ perturbs replication of these viruses signifying the role of PI4P and OSBP in enterovirus replication (Greninger et al., 2012; Rönnberg et al., 2012; Nchoutmboube et al., 2013; Téoulé et al., 2013; Lei et al., 2017; Lu et al., 2020).