FSCN1 and adrenal cortex carcinoma: More recently, we have demonstrated that the quantitative FSCN1 expression, detected by immunohistochemistry and quantitative RT-PCR in the tumor mass, may also represent a prognostic biomarker able to implement the predictive power of the current ACC histological classification (7), as high expression levels of FSCN1 positively associated with the invasive characteristics of ACC (7).