Tumor cells of case No. 2 were positive for AE1/AE3 (Figure 3A), CK7, calretinin (Figure 3B), D2-40, focal positive for WT-1 (Figure 3C), and negative for HMB45, Melan-A, Desmin, S100, Syn, CgA, CD31, and CD34. This evidence concerns the gene DES and neoplasm.