Most importantly, the ROC AUC score of TMB was 0.780, which was the most reliable indicator in the survival prediction of the model compared with age (AUC = 0.658), gender (AUC = 0.421), AJCC-T (AUC = 0.668), N (AUC = 0.566), M (AUC = 0.611), tumor stage (AUC = 0.708), or BRAF status (AUC = 0.520) (Figure 3J). The gene discussed is BRAF; the disease is neoplasm.