INS and type 2 diabetes mellitus: While insulin-induced hypoglycemia did not alter plasma VEGF levels in either control or T2D subjects (Figure 4B), plasma SEMA3A levels significantly decreased at hypoglycemia in control cases compared to baseline (799 ± 27 vs 935 ± 45 RFU of SEMA3A in control, hypoglycemia vs baseline, p=0.01) (Figure 4C).