ADAM17 and Hyperglycemia: To determine whether hyperglycemia affects the levels of RAS or sNRP1 associated proteins, we performed correlation analysis between the change in blood glucose from hyperglycemia (baseline) to normoglycemia with basal levels of plasma RAS-related proteins (Renin, ANG and ACE2) (Supplementary Figure 1A) and plasma sNRP1 related proteins (sNRP1, VEGF, SEMA3A and ADAM17) (Supplementary Figure 1B).