Stratification of plasma levels of sNRP1, VEGF, SEMA3A and ADAM17 based on gender demonstrated no significant differences in their levels at baseline or hypoglycemia in control subjects (Supplementary Figures 2A, B); nor at baseline, normoglycemia, or hypoglycemia in T2D subjects (Supplementary Figures 2C–E). Here, ADAM17 is linked to Hypoglycemia.