Interestingly, in T2D, ADAM9 levels increased sharply 4-hours post-hypoglycemia compared to either the 2h post-hypoglycemia timepoint (1356 ± 81 vs 1019 ± 68 RFU of ADAM9 4h post-hypo vs 2h post-hypo, p<0.01) or baseline (1356 ± 81 vs 1107 ± 60 RFU of ADAM9 4h post-hypo vs baseline, p<0.05) (Figure 4A). Here, ADAM9 is linked to Hypoglycemia.