Baseline levels of sNRP1 did not differ between T2D and controls (2298 ± 385 vs 2279 ± 488 RFU, T2D vs control, p=ns); normalization of glucose in T2D did not alter sNRP1 (2298.1 ± 80.3 vs 2279.1 ± 101.6 RFU of NRP1, T2D vs control, p=ns) (Figure 2A), and levels were unchanged in response to insulin induced normalization of glycemia (in T2D) (Figure 2A) and hypoglycaemia (both in control and in T2D) (Figure 2B). The gene discussed is INS; the disease is type 2 diabetes mellitus.