Hypoglycemia resulted in alteration of the complement and coagulation cascades with an increase in thrombospondin, platelet factor 4, platelet basic protein (NAP-2 or PPBP), and vitamin K-dependent protein C. Vitamin K-dependent protein C functions as a natural anticoagulant to downregulate thrombin generation in the clotting cascade with cardioprotective properties (21), and therefore its elevation shown here may be seen to be protective. This evidence concerns the gene PF4 and Hypoglycemia.