IGFBP5 and obesity due to melanocortin 4 receptor deficiency: SULT1A1 (56), SULT1A2 (56), COL6A1 (57), COL6A2 (58), SOS1 (59), STAT1 (60), COL5A2 (61), RND3 (62), COL15A1 (63), CBS (cystathionine-beta-synthase) (64), MCM6 (65), TNFRSF12A (66), FMOD (fibromodulin) (67), TYMP (thymidine phosphorylase) (68), ALPL (alkaline phosphatase, biomineralization associated) (69), EFEMP1 (70), MFAP4 (71), IGFBP5 (72), GLUL (glutamate-ammonia ligase) (73), HACD1 (74) and SCP2 (75) have been reported to be biomarkers of heart disease or play a vital role in its pathogenesis, but these genes might be novel target for obesity.