LMO2 (175), MSN (176), TAGLN2 (177), SRSF3 (178), SAFB (179), SIN3A (180), TRIM24 (181) and AUTS2 (182) appears to be constitutively activated in cancer, but these genes might be novel target for obesity. This evidence concerns the gene SAFB and obesity due to melanocortin 4 receptor deficiency.