Pathway enrichment analysis revealed that the up regulated genes were mainly enriched in thyroid hormone metabolism II (via conjugation and/or degradation), ECM-receptor interaction, IL6-mediated signaling events, collagen formation, C21 steroid hormone metabolism, genes encoding collagen proteins, integrin signalling pathway, hypertension and suprofen pathway, and are listed in Supplementary Table 3. Here, IL6 is linked to hypertensive disorder.