Several studies have shown that expressions of COL1A2 (76), COL3A1 (77), EEF2K (78), ANGPT1 (79), NOTCH3 (80) and TGFBR2 (81) can be a strong prognosis biomarker in patients with hypertension, but these genes might be novel target for obesity. Here, COL3A1 is linked to obesity due to melanocortin 4 receptor deficiency.