LMO2 (175), MSN (176), TAGLN2 (177), SRSF3 (178), SAFB (179), SIN3A (180), TRIM24 (181) and AUTS2 (182) appears to be constitutively activated in cancer, but these genes might be novel target for obesity. The gene discussed is MSN; the disease is obesity due to melanocortin 4 receptor deficiency.