They also investigated the role of epigenetic modifications in the decreased NRF2 binding at glutamate-cysteine ligase catalytic subunit (Gclc)-ARE4 and showed that H3K4me2 at Gclc-ARE4 was elevated, H3K4me3 and H3K4me1 as well as NRF2 binding at Gclc-ARE4 were reduced in DM. The gene discussed is NFE2L2; the disease is diabetes mellitus.