SIRT1 and familial dilated cardiomyopathy: found that long ncRNA (lncRNA) HOX transcript antisense RNA (HOTAIR) and Sirt1 were downregulated but miR-34a was upregulated in diabetic hearts and HG-stimulated H9c2 cells, while overexpression of lncRNA HOTAIR protected against DCM via increasing Sirt1 expression by sponging miR-34a (39).