NFE2L2 and cancer: Many antioxidant compounds have been proposed to regulate nfe2l2 expression by modulating DNA methylation at the CpG sites of the promoter sequence of nfe2l2. Resveratrol, widely found in grapes, mulberries, peanuts, and red wine, is a natural phenolic compound with strong anti-inflammatory, antioxidant, and anti-cancer properties (65–68).