In a recent study, CSF amyloid-beta (Aβ)1–42, total tau (T-Tau), and phosphorylated tau (p-Tau) ratios, showed their clinical utility for differentiating AD from non-AD neurodegenerative dementias, distinguishing AD from both bvFTD and semantic dementia (SD, sensitivities, and specificities of 80–90%) (167). The gene discussed is MAPT; the disease is Alzheimer disease.