In a cross-sectional study of patients with a mutation in the gene CHMP2B associated frontotemporal dementia, levels of inflammatory markers such as CCL4 IL-15, CXCL10, CCL22, and TNF-α were found increased and significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration (206). This evidence concerns the gene CHMP2B and frontotemporal dementia.