Five studies(45, 47, 25, 26; and our study), including a total of 621 patients with ALS and 368 controls, were included in the meta-analysis of IgA (Supplementary Table 2), and no significant differences in serum IgA levels between patients with ALS and controls were identified (Figure 2D). This evidence concerns the gene CD79A and amyotrophic lateral sclerosis.