The ventromedial hypothalamus (VMH) is a key area of integration (Klockener et al., 2011; Lim et al., 2016) and exposure to an obesogenic environment during early development may program the VMH of adult offspring to exhibit changes in the sensitivity to leptin and insulin, leading to hypertension and sympatho-excitation (Prior et al., 2014). The gene discussed is INS; the disease is hypertensive disorder.