IL1A and asthma: In line with data reporting increased IL-1α in BALF from asthma patients (Willart et al., 2012), airway epithelial cells from asthma patients released more IL-1α that controls in early redifferentiation time points in ALI culture, and IL-1α induced proinflammatory responses in fibroblasts (Osei et al., 2020), further supporting the role of IL-1α in dysregulating of EMTU in chronic respiratory diseases.