SPDEF and asthma: Jag1/Notch2 activation subsequently induces both downregulation of ciliated cells marker FOXJ1 and upregulation of goblet cells transcriptional factor SPDEF (Carrer et al., 2020), mimicking two central features of the asthma epithelial phenotype and further suggesting a role for Jag1/Notch2 signaling in the pathogenesis of abnormal epithelial lineage in asthma.