Although TLR profile expression comparison in control versus CF epithelial cell lines (16HBE14o and CFTE29o, respectively) and in wild-type versus CFTR–/– mice globally brings similar patterns (Muir et al., 2004; Greene et al., 2005), PA-exposed CF cells (IB3-1) produce more IL-6 than “CF-corrected” cells (C38), in a manner depending from TLR5/bacterial flagellin interaction (Blohmke et al., 2008). This evidence concerns the gene IL6 and cystic fibrosis.