According to Yan et al. (2003), Densmore et al. (2006), Chironi et al. (2009), Burger et al. (2013), Foley and Conway (2016), and Leopold (2020), the combination of factors mentioned in item 2 above may be caused by an increased concentration of Ang II, while the subsequent reduced amount of endothelial NO contributes to endothelial dysfunction and endotheliopathy. This evidence concerns the gene AGT and endothelial dysfunction.