PI3 and colitis: More specifically, Motta et al. demonstrated that administration of the endogenous elastase inhibitor elafin, by transgenic expression or via adenoviral delivery, significantly improved intestinal inflammation in acute and chronic dextran sodium sulfate (DSS), trinitrobenzene sulfonic acid (TNBS) and chronic T cell transfer colitis mouse models (Motta et al., 2011; Motta et al., 2012).