A recent study revealed that combining CD19-CAR-T cells and OVs encoding for truncated CD19 (OV19t) achieved a >50% cure rate in a mouse tumor model by inducing local immunity characterized by tumor T cell infiltration; CAR T cell-mediated tumor killing also promoted viral release from dying tumor cells, further propagating CD19t tumor expression (Park et al., 2020). Here, CD19 is linked to neoplasm.