EGFR-CAR-NK cells induce potent cell lysis and increase IFN-γ production when co-cultured with GBM cells, and intracranial NK-EGFR-CAR cell injection can effectively inhibit tumor growth and significantly extend the life expectancy of orthotopic GBM animal models (Han et al., 2015). This evidence concerns the gene IFNG and glioblastoma.