EGFR-CAR-NK cells induce potent cell lysis and increase IFN-γ production when co-cultured with GBM cells, and intracranial NK-EGFR-CAR cell injection can effectively inhibit tumor growth and significantly extend the life expectancy of orthotopic GBM animal models (Han et al., 2015). The gene discussed is EGFR; the disease is glioblastoma.