In 2020, Zhong et al. demonstrated that B7-H3 contributed to epithelial-mesenchymal transition (EMT) development via E-cadherin down-regulation and MMP2/9 up-regulation and promoted glioma progression and invasion through JAK2/STAT3/Slug-dependent signaling (Zhong et al., 2020). Here, CD276 is linked to central nervous system cancer.