We deduced that BZBS can reduce vascular endothelial cell pyroptosis through ERα-mediated activation of autophagy or the following regulation of the expressions of SREBPs and SIRT1 to improve atherosclerosis in post-menopausal stage (Chen, et al., 2020; Meng et al., 2021a). The gene discussed is ESR1; the disease is atherosclerosis.