CLEC4E and chronic kidney disease: Treatment with an Astragalus mongholicus Bunge (Leguminosae) and Panax notoginseng (Burkill) F.H.Chen (Araliaceae) formulation in combination with Bifidobacterium was found to protect kidneys in CKD by decreasing macrophage inflammatory response in the kidney and intestine via inhibiting Mincle signaling (Tan et al., 2020).