The systematic pharmacology prediction results showed that HCC may regulate CIR-related targets (such as AKT1, MAPK1, CASP3, EGFR), biological processes (such as inflammation, platelet activation, nerve cell survival, angiogenesis, oxidative stress, neuronal axonal injury, hypoxia-induced stress, blood coagulation, calcium homeostasis) and signaling pathways (such as HIF-1, VEGF, Ras, FoxO signaling). Here, MAPK1 is linked to hepatocellular carcinoma.