APP and Alzheimer disease: For example, AP39 is known to generally improve mitochondrial bioenergetics (Gero et al., 2016; Etheridge et al., 2017; Fox et al., 2021) and supplementation of APP/PS1 mouse model of AD P39 improved mitochondrial dynamics, shifting from fission toward fusion, ameliorated their spatial memory deficits and reduced Aβ deposition in their brains (Zhao et al., 2016).