The pathogenesis of AD includes the excessive aggregation of amyloid-β (Aβ) peptides, the presence of neurofibrillary tangles (NFTs) induced by the hyperphosphorylation of tau protein, neuroinflammation, and metabolic disturbances; however, the mechanisms underlying the pathogenesis of AD is not fully understood (Jagust, 2018). Here, MAPT is linked to Alzheimer disease.