In accordance, studies in animals showed that in the absence of LCN2 rodents display: (i) anxious and depressive-like behaviors, as well as cognitive impairment in spatial learning tasks (Ferreira et al., 2013); (ii) deficits in adult neural stem cells proliferation and commitment, with impact on the hippocampal-dependent contextual fear discriminative task (Ferreira et al., 2018, 2019). The gene discussed is LCN2; the disease is Cognitive impairment.